ANTIBACTERIAL PEPTIDES IN THE TREATMENT OF ACNE VULGARIS PATIENTS

Acne vulgaris is a multifactorial disease. Besides genomic regulatory mechanism and among numerous triggering factors Cutibacterium acnes is considered as one of the main pathogenic factors, that can activate the human humoral and cellular immune system, exhibiting a robust proinflammatory activity. The article provides an updated review of the data on current antimicrobial peptides that could be used as potential therapeutic agents against microorganisms located in the skin and related to acne disease, which embraces promise to solve the problem of antimicrobial resistance of cutibacterium acnes. The positive results of regular investigation of clinical efficacy of topical antimicrobial peptides GDP-20 in 33 acne vulgaris patients are presented.