ENDOGENOUS ESTROGEN LEVELS AFFECT SEXUAL FUNCTION IN ELDERLY POST-MENOPAUSAL WOMEN

Abstract Objective: The objective of this study was to determine if there is an association between endogenous serum concentration of estradiol (E 2 ) and changes in sexual function in post-menopausal women over 3 years. Methods: Sexually active women ( N =345, mean age=65 years) who participated in the multiple outcomes of raloxifene evaluation trial (MORE) had endogenous E 2 levels measured at baseline. All women completed the sexual history questionnaire at baseline and 3 years later. We assessed sexual function (desire, activity, feelings/experiences and sexual problems) among these women by endogenous E 2 level ( Results: At baseline, women with E 2 levels 2 ≥20 pmol/l ( P 2 ≥20 pmol/l had significantly less decline in sexual enjoyment ( P P P P =0.001), when compared with women who had E 2 levels Conclusions: Endogenous E 2 levels are important predictors of change in sexual function in elderly women who are sexually active. However, this result needs to be proven in a study with a bigger sample size of sexually active women, who present with changes in sexual function over several years. Also, future investigations are needed to assess the effects of other endogenous hormones on sexual function in elderly women.