EFFECT OF COLD EXPOSURE ON LIPOPROTEIN LIPASE ACTIVITY IN BROWN ADIPOSE TISSUE OF MICE

Publisher Summary This chapter discusses the effect of cold exposure on the lipoprotein lipase activity in the brown adipose tissue (BAT) of mice. BAT has been considered to play an important role in non-shivering thermogenesis. In BAT, the major control of heat production may greatly depend upon the rate of fatty acid oxidation. In an experiment described in the chapter, 3 to 4-month-old C57BL/6J mice were housed in a temperature-controlled room and were transferred to a cold room at a temperature of 4°C±1°C. LPL seems to be an important enzyme for the incorporation of fat from circulation. The maximal activity in cold was 10 times higher than that at room temperature. An increase of adrenalin sensitivity in NEFA release was also observed.