Erythrocytes modified (coated) gold nanoparticles for effective drug delivery

Abstract The main purpose of this chapter is to highlight the bioengineered erythrocyte cell-based drug delivery system and its application in modern therapeutics and special inference with gold nanoparticles (GNPs). For over a decade, there have been frequent efforts to address issues concerned with conventional treatment system, so that it provides greater therapeutic outcomes and overcome physiological barriers; for instance, synthetic delivery system, its relationship among physicochemical properties, hemodynamics, hemorheology, as well as delivery efficacy and safety. The inefficacy associated with these systems may be attributed to its poor transportation via blood flow, crossing the vasculature with sufficient circulations, intracellular trafficking limitations then its target specificity, validation, and clearance. Erythrocytes cell based and its targeted drug delivery objective aims to reduce drug-immune associated toxicities, improve precise therapeutic efficacy, and increase patient safety compliance. Its navigation in vasculatures avoids immune system, margination from dense blood flow to target sites, accumulation, and then its released patterns make it more prominent among other cell-based drug delivery systems. Currently, it is passing through its initial stages of progressions and advancement and needs further extensive researches and amplifications. This chapter is an attempt to properly present erythrocytes based GNPs and its therapeutic application in modern drug delivery system.