The novel Akt inhibitor, perifosine, induces caspase-dependent apoptosis and downregulates P-glycoprotein expression in multidrug-resistant human T-acute leukemia cells by a JNK-dependent mechanism.

Francesca Chiarini,M Del Sole,Sara Mongiorgi,Gc Gaboardi,Alessandra Cappellini,Irina Mantovani,My Follo,J A McCubrey,Am Martelli

The novel Akt inhibitor, perifosine, induces caspase-dependent apoptosis and downregulates P-glycoprotein expression in multidrug-resistant human T-acute leukemia cells by a JNK-dependent mechanism.

2008

Francesca Chiarini
M Del Sole
Sara Mongiorgi
Gc Gaboardi
Alessandra Cappellini
Irina Mantovani
My Follo
J A McCubrey
Am Martelli

The novel Akt inhibitor, perifosine, induces caspase-dependent apoptosis and downregulates P-glycoprotein expression in multidrug-resistant human T-acute leukemia cells by a JNK-dependent mechanism

Keywords:

Cancer research
Protein kinase B
Perifosine
Mitogen-activated protein kinase
P-glycoprotein
Caspase
Caspase-Dependent Apoptosis
Leukemia
Programmed cell death
Biology
Apoptosis

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