Clinical efficacy of vacuum sealing drainage joint liquid irrigation combined with topical oxygen therapy on deep burn wounds

Objective Evaluation of the therapeutic efficacy of vacuum sealing drainage (VSD) combined with topical oxygen therapy and liquid irrigation for deep burn wounds. Methods From January 2015 to June 2017, 30 patients with deep burn wounds required surgical treatment were divided into simple VSD group (n=9); VSD joint irrigation group (n=10); VSD combined with oxygen and liquid irrigation group (n=11) according to the random number table method after debridement. Post treatment of 7 days, overall situations of local wound and granulation tissue coverage rate were observed among three groups; the local tissue fluid partial pressure of oxygen was detected; Furthermore, the postoperative survival of skin graft or flap were calculated; Moreover the frequency of dressing change, days of antibiotic used and hospital stay after operation were recorded. Date were processed with one-way analysis of variance and LSD-t test. Results (1) VSD combined with oxygen and liquid irrigation group wound bed was better than VSD joint irrigation group and simple VSD group, VSD joint irrigation group was better than the simple VSD group after 7 days. Compared with that in simple VSD and VSD joint irrigation group [(68±9)%, (82±7)%], granulation tissue coverage rate [(95±4)%] was higher in VSD combined with oxygen and liquid irrigation group (t=13.53, 27.63; with P values below 0.01), there was significant difference between VSD joint irrigation group and simple VSD group (t=14.09, P 0.05). (3) The survival rate of skin graft and flap in VSD combined with oxygen and liquid irrigation group was the highest among 3 groups (with t values from 11.2 to 20.4, P values below 0.01), and in VSD joint irrigation group was higher than that in simple VSD group (t=4.43, 8.43; with P values below 0.05). (4) The frequency of dressing change, the days of antibiotic used and hospital stay in VSD combined with oxygen and liquid irrigation group were less than those in simple VSD group and VSD joint irrigation group (t=3.37, 5.95, 7.01, 6.25, 10.80, 13.26; with P values below 0.01), there was significant difference between VSD joint irrigation group and simple VSD group (t=2.79, 4.83, 6.24; with P values below 0.05). Conclusions VSD combined with oxygen and liquid irrigation can make full use of the advantages of three kinds of wound technologies. More effective in correcting the ischemia and hypoxia of wound tissue, providing fresh wound bed for repairing, improving skin graft or flap survival, promoting the clinical efficacy. Key words: Burns; Negative-pressure wound therapy; Oxygen; Skin transplantation; Regional perfusion