Eu3+-doped layered gadolinium hydroxides as drug carriers and their bactericidal behavior

Layered rare earth hydroxides (LRHs) due to outstanding photoluminescence (PL) properties and anion exchangeability are extensively reported in multiple fields. In this work, the drug-loaded and bactericidal behaviors of Eu3+-doped layered gadolinium hydroxides (LGdHs:Eu) as optical carriers were explored through intercalation and release of cephalexin (CE). In the intercalation state, the PL intensity of CE--LGdHs:Eu obviously decreased because of the quenching effect of CE-. And the PL intensity of LGdHs:Eu was restored with the release of CE- ions in phosphate buffer solutions (PBS). A significant functional relationship between the drug releasing amount and PL intensity ratio was found, providing a novel optical method to specify the drug dosage. And CE--LGdHs:Eu showed the excellent bactericidal properties in both in vivo and in vitro experiments.