Total Synthesis of Indolizidine (+)‐223A

We described the diastereoselective total synthesis of indolizidine (+)-223A in 10 % overall yield over 14 steps starting from 6-chlorohex-2-ynoate. Our strategy involved chain elongation through aldolization, the formation of the indolizidine skeleton by cyclization, and stereocontrolled hydrogenation.