The Cell Cycle and the Molecular Biology of Cancer
2007
Human malignant tumors are characterized by abnormal proliferation resulting from alterations in cell-cycle regulatory mechanisms. The regulatory pathways controlling cell-cycle phases include several oncogenes and tumor suppressor genes, which display a range of abnormalities with potential usefulness as markers of evolution or treatment response in cancer. This chapter summarizes the current knowledge about these aberrations in malignant transformation.
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