Ключевые слова: доклиническая фармакокинетика, аналог гипоталамического гормона соматостатина.

As part of pre-clinical pharmacokinetic study of the dosage form of the hypothalamic hormone somatostatin analogue has been developed a method for 3 H-AGG by synthesis of 3 H-tetrapeptide obtained by the bombardment of molecules thermally active substances with gaseous tritium, and cysteine. Pharmacokinetic studies AGG in 15 tissues and organs of mice when administered in the dosage form of the drug showed good accessibility to all organs and tissues, including Sa755, and a high affinity to the stomach and bone marrow. Withdrawal from the study of the animal organism in the urine and feces showed that the cumulative excretion of respectively 16 % and 78 %, and mostly ends in 24h surveillance.