Development of photoaffinity probes for γ-secretase equipped with a nitrobenzenesulfonamide-type cleavable linker

Satoshi Yokoshima,Yuzo Abe,Naoto Watanabe,Yoichi Kita,Toshiyuki Kan,Takeshi Iwatsubo,Taisuke Tomita,Tohru Fukuyama

Development of photoaffinity probes for γ-secretase equipped with a nitrobenzenesulfonamide-type cleavable linker

2009

Satoshi Yokoshima
Yuzo Abe
Naoto Watanabe
Yoichi Kita
Toshiyuki Kan
Takeshi Iwatsubo
Taisuke Tomita
Tohru Fukuyama

We have developed photoaffinity probes for γ-secretase with a nitrobenzenesulfonamide-type linker that can be cleaved with 2-mercaptoethanol under physiological conditions.

Keywords:

Organic chemistry
Linker
Amyloid precursor protein secretase
Photoaffinity labeling
Amyloid precursor protein
Carboxamide
Biotinylation
Dipeptide
Stereochemistry
Biochemistry
Peptide
Chemistry
Chemical synthesis

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