A SIMPLE AND HIGHLY EFFICIENT SYNTHESIS OF QUINOLINE TERTIARY AMINES CATALYZED BY HUNIG'S BASE

Substituted 2-methyl-4-chloroquinoline 4 (a-d) were treated with secondary amines in DMF at RT for 3hrs in the presence of Hunig’s base to obtain quinoline tertiary amines 5(a-p). The reactions went smoothly without forming any quaternary ammonium salt as side products.