Effect of Streptococcal Hyaluronic Acid (SHA) in Mice, Rats, Rabbits and Dogs

SummarySodium hyaluronate prepared from a virulent strain of Streptococcus pyogenes was injected intravenously and in-traperitoneally into mice, rats, rabbits and dogs. Single injections up to 1 g/kg body weight and repeated daily injections up to 100 mg/kg for periods of 10 to 42 consecutive days failed to produce pathological changes in the tissues. There was no evidence that this material was stored and it appeared to be either metabolized or excreted in the urine.