Efficacy and safety of single agent pertuzumab (rhuMAb 2C4), a HER dimerization inhibitor, in hormone refractory prostate cancer after failure of taxane-based therapy

4624 Background: Pertuzumab (P), a humanized HER2 antibody, inhibits dimerization of HER2 with other HER kinase family members (EGFR, HER3 and HER4), thereby inhibiting signaling through MAP and PI...