4,2',4'-triethoxy-5' substituted chalcone derivatives and preparation method and application thereof

The invention relates to 4,2',4'-triethoxy-5' substituted chalcone derivatives, a preparation method and application of the derivatives to an antitumor medicines. Two compounds refer to 4,2',4'-triethoxy-5' (p-methoxyphenyl) chalcone and 4,2',4'-triethoxy-5' (p-fluorophenyl) chalcone. Two 4,2',4'-triethoxy-5' substituted chalcone derivatives are synthesized for the first time, and the in-vitro tumor cell inhibiting activities of the derivatives are tested. As indicated by results, the derivatives have high inhibiting activity to human erythroleukemia cells (K562) and human colon cancer cells (HT-29).