Letter by Rus et al Regarding Article, “RGC-32 (Response Gene to Complement 32) Deficiency Protects Endothelial Cells From Inflammation and Attenuates Atherosclerosis”
2018
The recently published article by Cui et al1 sheds new light on the role of RGC-32 (response gene to complement 32) in atherogenesis. This interesting article describes a new mechanism of action of RGC-32 in inducing the expression of the endothelial cell adhesion molecules ICAM-1 and VCAM-1, which are necessary for monocyte recruitment into the atherogenic lesion core. We would like to add a few comments on several findings reported in this article.
We have also examined the expression of RGC-32 in the human aortic atherosclerotic wall.2 We found that RGC-32 was expressed in human aortic atherosclerotic lesions: by endothelial cells, by inflammatory cells (CD4+ and CD68+ cells) in intimal thickenings and fibrous …
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