Hypothesis to explain the association between hypocalciuria and low circulating 1, 25-dihydroxyvitamin D levels in preeclampsia

Abstract A hypothesis is presented according to which the hypocalciuria in preeclamptic women is due to a decreased efficiency of intestinal calcium absorption as a consequence of diminished placental synthesis of 1,25-dihydroxyvitamin D related to lower circulating placental lactogen level and/or a possible reduction in the synthesis of insulin-like growth factor I.