Migraine and depression: biological aspects.

Summary-There is a considerable overlap in migraine and depression incidence, and both conditions may be associated with low levels of 5hydroxytryptamine (5-HT). During a migraine attack there is evidence for low levels of platelet 5-HT and possibly also low Vmax for S-HT uptake; both these findings are also associated with the depressed state. Both conditions can be treated by tricyclic and monoamine oxs during the headache phase of the attack, the links with depression are most apparent.