Quinoline compound, and preparation method, intermediate, medicinal composition and application thereof

The invention discloses a quinoline compound, and a preparation method, an intermediate, a medicinal composition and an application thereof/ The invention provides a quinoline compound represented by formula 1 shown in the specification, and its pharmaceutically acceptable salts, solvates, metabolites, metabolism precursors or medicinal precursors. The quinoline compound has a good inhibition effect on tyrosine kinases C-Met, and can be used for preparing medicines for prevention, treatment or adjuvant treatment of many C-Met expression or activity related diseases, especially tumor diseases.