NLRC5: A paradigm for NLRs in immunological and inflammatory reaction

Abstract The nucleotide-binding domain leucine-rich repeat containing (NLR) family of proteins is mainly involved in microbial pathogen recognition, inflammatory responses, and cell death. NLRC5, the largest member of the NLR family, is currently receiving an increasing level of attention. NLRC5 has been demonstrated to be a potent negative regulator of NF-κB signaling pathway-mediated inflammatory response. Moreover, accumulating evidence has indicated that NLRC5 is closely related to pathological processes of various cancers. In this review, we present an overview on NLRC5, addressing its underlying molecular mechanisms and implications in host defense, inflammatory response, and associated cancers.