Disposition of Q-35(3): Transfer into Fetus and Milk in Rats

Transfer of radioactivity into fetus and milk were studied after a single oral administration of 14C-Q-35 at the dose of 20 mg/kg in pregnant and in lactating rats.1. Whole body autoradiography of pregnant rats showed that radioactivity distributed well and rapidly in the body, except brain and eye ball. At 24 h after administration, radioactivity in tissues was almost completely eliminated.Distribution patterns of radioactivity in fetus were similar to those in mother. However, the radioactivity in fetus was relatively low.2. The levels of radioactivity in milk were higher than those in plasma suggesting that Q-35 transfers into milk.