Discovery of CP-199,330 and CP-199,331: Two potent and orally efficacious cysteinyl LT1 receptor antagonists devoid of liver toxicity
1999
Abstract CP-199,330 ( 3 ) and CP-199,331 ( 4 ) are cysLT 1 receptor antagonists that are equipotent to marketed cysLT 1 receptor antagonists zafirlukast and pranlukast, show good pharmacokinetics in rats and monkeys, and are devoid of liver toxicity in monkeys as seen in CP-85,958 ( 1 ).
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