A central role for Notch in effector CD8 + T cell differentiation

Ronald Backer,Christina Helbig,Rebecca Gentek,Andrew Kent,Brian J. Laidlaw,Claudia X. Dominguez,Yevan de Souza,Stella E. van Trierum,Ruud van Beek,Guus F. Rimmelzwaan,Anja ten Brinke,A. Marcel Willemsen,Antoine H. C. van Kampen,Susan M. Kaech,J. Magarian Blander,Klaas P. J. M. van Gisbergen,Derk Amsen

A central role for Notch in effector CD8 + T cell differentiation

2014

Ronald Backer
Christina Helbig
Rebecca Gentek
Andrew Kent
Brian J. Laidlaw
Claudia X. Dominguez
Yevan de Souza
Stella E. van Trierum
Ruud van Beek
Guus F. Rimmelzwaan
Anja ten Brinke
A. Marcel Willemsen
Antoine H. C. van Kampen
Susan M. Kaech
J. Magarian Blander
Klaas P. J. M. van Gisbergen
Derk Amsen

Activated CD8+ T cells must 'choose' between the terminal effector cell fate or the memory precursor cell fate. Amsen and colleagues find that the cell surface receptor Notch controls this 'choice'.

Keywords:

Cell biology
Immunology
Precursor cell
Cytotoxic T cell
Cellular differentiation
Cell surface receptor
Biology
CD8
Acquired immune system
Notch signaling pathway
Effector

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