Влияние производного глутаминовой и аповинкаминовой кислот на метаболизм головного мозга в постишемическом периоде

Neuroprotective properties of the new derivative of glutamic and apovincaminic acids, ethyl-(3-α,16-α)-eburnamenin-14-carbopxylate of 2-aminopentadionic acid (LHT 1-02) were studied on a model of acute brain ischemia in cats. LHT 1-02 has proved to be more effective than the reference drugs vinpocetin and glycine in preventing the reperfusive damage, which was manifested by decreased postischemic hyperglycemia, activated utilization of oxygen in the brain, and suppressed postischemic metabolic lactate acidosis. Thus, the results of this comparative study show expediency of further investigations of LHT 1-02 as a potential neuroprotective drug.