Analysis of baseline liver biochemical parameters in 324 cases with novel coronavirus pneumonia in Shanghai area

Objective: To summarize the clinical characteristics and liver biochemical parameters of 324 cases admitted with novel coronavirus pneumonia in Shanghai area. Methods: Clinical data and baseline liver biochemical parameters of 324 cases with novel coronavirus pneumonia admitted to the Shanghai Public Health Clinical Center from January 20, 2020 to February 24, 2020 were retrospectively analyzed. Patients were divided into two groups based on the status of illness: mild type (mild and typical) and severe type (severe and critical).The differences in clinical data and baseline liver biochemical parameters of the two groups were described and compared. The t-test and Wilcoxon rank-sum test were used for measurement data. The enumeration data were expressed by frequency and rate, and chi-square test was used. Results: Of the 324 cases with novel coronavirus pneumonia, 26 were severe cases (8%), with median onset of 5 days, 20 cases were HBsAg positive (6.2%), and 70 cases (21.6%) with fatty liver, diagnosed with X-ray computed tomography. Alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), γ-glutamyl transferase (GGT), total bilirubin (TBil), albumin(ALB) and international normalized ratio (INR) of 324 cases at baseline were 27.86 ± 20.02 U/L, 29.33 ± 21.02 U/L, 59.93 ± 18.96 U / L, 39.00 ± 54.44 U/L, 9.46 ± 4.58 μmol / L, 40.64 ± 4.13 g / L and 1.02 ± 0.10. Of which, ALT was > than the upper limit of normal (> ULN), accounting for 15.7% (51/324). ALT and AST > ULN, accounting for 10.5% (34/324). ALP > ULN, accounting for 1.2% (4/324). ALP and GGT > ULN, accounting for 0.9% (3/324). INR > ULN was lowest, accounting for 0.6% (2/324). There were no statistically significant differences (P > 0.05) in ALT [(21.5 vs. 26) U / L, P = 0.093], ALP [(57 vs.59) U/L, P = 0.674], and GGT [(24 vs.28) U/L, P = 0.101] between the severe group and the mild group. There were statistically significant differences in AST (23 U/L vs. 34 U/L, P 正常值上限（ULN）占15.7%（51/324），丙氨酸转氨酶和天冬氨酸转氨酶均> ULN占10.5%（34/324），碱性磷酸酶> ULN占1.2%（4/324）,碱性磷酸酶和γ-谷氨酰转移酶均> ULN占0.9%（3/324），国际标准化比值> ULN比例最低为0.6%（2/324）。重症组与轻症组相比丙氨酸转氨酶（21.5 U/L比26.0 U/L，P = 0.093）、碱性磷酸酶（57 U/L比59 U/L，P = 0.674）、γ-谷氨酰转移酶（24 U/L比28 U/L，P = 0.101）差异均无统计学意义（P值均> 0.05），天冬氨酸转氨酶（23 U/L比34 U/L，P < 0.01），总胆红素（10. 5 μmol/L比8.05 μmol/L，P < 0.01）、白蛋白[（35.79±4.75） g/L比（41.07±3.80）g/L，P < 0.01]、国际标准化比值（1.00比1.04，P < 0.01）差异均有统计学意义。 结论： 上海地区324例新型冠状病毒肺炎患者基线肝脏生物化学指标异常比例较低且肝损伤程度轻，胆管细胞损伤少见。.