Benzoic Acid Catalyzed Annulations of α‐Amino Acids and Aromatic Aldehydes Containing an ortho‐Michael Acceptor: Access to 2,5‐Dihydro‐1H‐benzo[c]azepines and 10,11‐Dihydro‐5H‐benzo[e]pyrrolo[1,2‐a]azepines.

Mi Tang,Lingfeng Tong,Lei Ju,Wanwan Zhai,Yang Hu,Xinhong Yu

Benzoic Acid Catalyzed Annulations of α‐Amino Acids and Aromatic Aldehydes Containing an ortho‐Michael Acceptor: Access to 2,5‐Dihydro‐1H‐benzo[c]azepines and 10,11‐Dihydro‐5H‐benzo[e]pyrrolo[1,2‐a]azepines.

2016

Mi Tang
Lingfeng Tong
Lei Ju
Wanwan Zhai
Yang Hu
Xinhong Yu

A broad range of the title substrates reacts with proline, sarcosine or L-thioproline following a rapid microwave-assisted approach to provide 2,5-dihydro-1H-benzo[c]azepines in high yields.

Keywords:

Proline
Sarcosine
Amino acid
Catalysis
Benzoic acid
Chemistry
Michael reaction
Organic chemistry

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