A Review of Neuroimaging-driven Brain Age Estimation for identification of Brain Disorders and Health Conditions.

BACKGROUND Neuroimage analysis has made it possible to perform various anatomical analyses of the brain regions and helps detect different brain conditions/ disorders. Recently, neuroimaging-driven estimation of brain age is introduced as a robust biomarker for detecting different diseases and health conditions. OBJECTIVE To present a comprehensive review of brain age frameworks concerning: i) designing view: an overview of brain age frameworks based on image modality and methods used, and ii) clinical aspect: an overview of the application of brain age frameworks for detection of neurological disorders or health conditions. METHODS PubMed is explored to collect 136 articles from January 2010 to June 2021 using Brain Age Estimation and Brain Imaging, along with combinations of other radiological terms. RESULTS & CONCLUSION The studies presented in this review are evidence of using brain age estimation methods in detecting various brain diseases/conditions. The survey also highlights tools and methods for brain age estimation and addresses some future research directions.