Effects of Mad Honey on Blood Glucose and Lipid Levels in Rats With Streptozocin-Induced Diabetes

This study investigated whether mad honey affects blood glucose and lipid levels in experimental animals. It was found that mad honey caused significant decreases in blood glucose and lipid levels in animals with streptozocin-induced diabetes mellitus (n = 10) and controls (n = 10). These decreases may be due to grayanotoxins in the mad honey causing the islets of Langerhans in the pancreas to secrete insulin by stimulating the parasympathetic nervous system or M2-muscarinic receptors. Ozet: Bu cal›flmada, deney hayvanlar›nda deli bal›n kan glukoz ve lipid seviyeleri uzerine etkisi olup olmad›¤›n› araflt›rmak amaclanm›flt›r. Deli bal›n hem streptozosin induklu diabetes mellituslu (n = 10) hem de kontrol (n = 10) hayvanlar›nda kan glukoz ve lipid seviyelerinde anlaml› bir duflmeye sebep olduu bulundu. Kan glukoz ve lipid seviyelerindeki bu duflufl, deli balda bulunan grayanotoksinlerin parasempatetik sinir sistemini veya M2-muskarinik reseptorleri uyararak pankreas Langerhans adac›k hucrelerinden insulin salg›latmas›na bal› olabilir.