Application of Solid Dispersion to Enhance Dissolution Properties of Mefenamic Acid with Casein.

The mefenamic acid (MFA)-casein solid dispersions were prepared for the purpose of enhancing the dissolution properties of MFA by two different methods, lyophilization and solvent evaporation.In the case of the solid dispersions prepared by the lyophilization method, the X-ray diffraction patterns indicated that MFA in the solid dispersion lost its crystalline property. But diffraction peaks still remained in the solid dispersion prepared by the solvent evaporation method.The dissolution rate of solid dispersions prepared by lyophilization method markedly increased, and the solid dispersion at 1: 3 w/w mixing ratio of MFA to casein gave the maximum amount of dissolution which was three times as much as that of MFA alone.It was suggested that supersaturation of MFA in dissolution medium was caused by the crystalline inhibitory effect of the casein.In the case of the solid dispersions prepared by the lyophilization method, the X-ray diffraction patterns indicated that MFA in the solid dispersion lost its crystalline property. But diffraction peaks still remained in the solid dispersion prepared by the solvent evaporation method.The dissolution rate of solid dispersions prepared by lyophilization method markedly increased, and the solid dispersion at 1: 3 w/w mixing ratio of MFA to casein gave the maximum amount of dissolution which was three times as much as that of MFA alone.It was suggested that supersaturation of MFA in dissolution medium was caused by the crystalline inhibitory effect of the casein.