Genomic deletion of malic enzyme 2 confers collateral lethality in pancreatic cancer

Prasenjit Dey,Joelle Baddour,Florian Muller,Chia Chin Wu,Huamin Wang,Wen Ting Liao,Zangdao Lan,Alina Chen,Tony Gutschner,Ya'an Kang,Jason B. Fleming,Nikunj Satani,Di Zhao,Abhinav Achreja,Lifeng Yang,Jiyoon Lee,Edward F. Chang,Giannicola Genovese,Andrea Viale,Haoqiang Ying,Giulio Draetta,Anirban Maitra,Y. Alan Wang,Deepak Nagrath,Ronald A. DePinho

Genomic deletion of malic enzyme 2 confers collateral lethality in pancreatic cancer

2017

Depletion of malic enzyme 3 in pancreatic cancer cells that have a deletion of the gene for malic enzyme 2 selectively kills the cells, suggesting that the enzyme might represent a therapeutic target for this subset of cancers.

Keywords:

Lethality
Enzyme
Pancreatic cancer
Malic enzyme
Cancer research
Genetics
Gene
Biology
Gene isoform
AMP-activated protein kinase
Sterol regulatory element-binding protein
Oxidative phosphorylation
Biochemistry
NADPH regeneration

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