Relative study on neuroendocrine changes and clinical characteristics in depression patients

Objective To discuss the correlation between neuroendocrine changes and clinical features in patients with depression. Methods The neuroendocrine data in patients with depression were collected and analyzed by Hamilton Depression Scale (HAMD) and Hamilton anxiety scale (HAMA). Results ①There were significant differences between the weight factor(normal group: 0.87±0.87; abnormal group: 1.09±0.87) and the sleep factor(normal group: 4.22±1.82; abnormal group: 4.54±1.84) of hypothalamic-pituitary-thyroid axis (HPT). ②There were significant differences between somatic anxiety factor(lower than the normal group: 7.87±4.65; normal group: 6.27±3.03; higher than the normal group: 6.44±2.46) and retardation factor(lower than the normal group: 9.22±4.27; normal group: 8.01±2.9; higher than the normal group: 7.41±1.92)of thyroid-stimulating hormone (TSH). ③There were significant differences between the weight factor and the retardation factor of serum free three iodine gland of the original acid(FT3). ④The weight factor of 3, 5, 3-three triiodothyronine (TT3) was significant.⑤There was no significant statistically difference in the rest groups. Conclusions The hormone abnormality of HPT axis can lead to sleep disorders and loss of weight in patients with depression.The reduction of TSH and FT3 can increase the symptoms of mental retardation in patients with depression.The decrease of TSH and FT3 can lead to weight loss in patients with depression and the decrease of TSH can increases somatic anxiety in patients with depression. Key words: Depression; Neuroendocrine; Clinical characteristics