MOESM2 of ELQ-331 as a prototype for extremely durable chemoprotection against malaria

Martin J. Smilkstein,Sovitj Pou,Alina Krollenbrock,Lisa Bleyle,Rozalia Dodean,Lisa Frueh,David J. Hinrichs,Yuexin Li,Thomas Martinson,Myrna Y. Munar,Rolf Winter,Igor Bruzual,Samantha Whiteside,Aaron Nilsen,Dennis R. Koop,Jane Xu-Kelly,Stefan H. I. Kappe,Brandon Wilder,Michael Kevin Riscoe

MOESM2 of ELQ-331 as a prototype for extremely durable chemoprotection against malaria

2019

Martin J. Smilkstein
Sovitj Pou
Alina Krollenbrock
Lisa Bleyle
Rozalia Dodean
Lisa Frueh
David J. Hinrichs
Yuexin Li
Thomas Martinson
Myrna Y. Munar
Rolf Winter
Igor Bruzual
Samantha Whiteside
Aaron Nilsen
Dennis R. Koop
Jane Xu-Kelly
Stefan H. I. Kappe
Brandon Wilder
Michael Kevin Riscoe

Additional file 2. Assessment of a method to limit ex vivo conversion of ELQ-331 to ELQ-300; Generalized method for estimation of compound solubility in sesame oil; ELQ-331 solubility in several solubilizing excipients; and Quantitation of radiance data from IVIS imaging displayed in TableÂ 4 of the main paper.

Keywords:

Prodrug
Solubility
Ex vivo
Chemoprotection
Chromatography
Chemistry
sesame oil
long acting

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