Are we improving the outcomes of metastatic breast cancer (MBC)? A single academic institution experience.

1105 Background: Over the last two decades we have seen a tremendous improvement in the outcomes of patients with early stage breast cancer. There is limited literature if we are improving the survival of our patients with MBC. Methods: We conducted a chart review of two cohorts of MBC patients ≥ 18 years at a cancer centre in Canada. The early cohort comprised of women seen between 1997-2002; the late cohort consisted of women seen between 2007-2010. Tumor characteristics and survival between the 2 cohorts were compared. Results: A total of 295 cases were reviewed of which 274 met inclusion criteria. Of these, 126 belonged to the early cohort and 148 to the late cohort. Age at diagnosis was similar in the two groups (average age=58 years). Fewer cases in the late cohort had grade III disease (35.7% vs. 25.0%, p=0.007). With respect to BC subtypes, 73.1% of late cohort cases were ER+ (vs. 68.2%, p=0.400); 19.7% were Her2+ (vs. 16.3%, p=0.021); 14.5% were Triple Negative (vs. 15.8%, p=0.854). Chemotherapy ...