Abstract PO-029: Using treatment to determine ECOG performance status in metastatic pancreatic cancer

Aim: ECOG Performance status (PS) is a major prognostic factor in patients with metastatic pancreatic cancer (mPAC) and is one of key factors to consider in treatment selection. However, there is limited ability to determine PS through administrative claims. We aimed to establish PS based on first-line (1L) treatment to describe characteristics of mPaC patients in a claims database. Methods: The IBM MarketScan database was used to identify adult, treated mPaC patients from 2014-2018. Those with other primary cancers or pregnant during the study, chemotherapy in the 6 month pre-diagnosis (baseline) period prior to first mPaC diagnosis or those without continuous enrollment in this time were excluded. PS was assumed by NCCN guideline-recommended first-line treatment for PS. Those with first-line FOLFIRINOX or gemcitabine + nab-paclitaxel were good performers. Those with first-line gemcitabine monotherapy or gemcitabine + (capecitabine or erlotinib) were poor performers. Patients with any other first-line treatment were ungrouped. Patient characteristics were measured in the 6-month baseline period or at mPaC diagnosis. Treatment patterns were measured during the variable length follow-up which ended due to disenrollment or end of study (12/31/2018). Results: A total of 1,737 mPaC patients met all inclusion criteria, of which 59.6% were categorized as good performers and 11.6% as poor performers. Poor PS was mainly identified by gemcitabine monotherapy (99.5%) while good PS was split between gemcitabine+nab-paclitaxel (54.9%) and FOLFIRINOX (45.1%). Patients were mostly male (56.0%) with a median follow-up of 202 days and no difference by PS. Poor performers (vs. good) were significantly older (mean age 67.5 vs 61.1 years, p Citation Format: Suvina Amin, Elisabetta Malangone-Monaco, Virginia Noxon, Seongiung Joo, Michael J. Pishvaian. Using treatment to determine ECOG performance status in metastatic pancreatic cancer [abstract]. In: Proceedings of the AACR Virtual Special Conference on Pancreatic Cancer; 2020 Sep 29-30. Philadelphia (PA): AACR; Cancer Res 2020;80(22 Suppl):Abstract nr PO-029.