Modulation of the immune response by the receptor NKp65 and its ligands

Use of a substance for blocking the NKp65 receptor complex for the manufacture of a medicament for the treatment and / or prevention of inflammatory and autoimmune diseases, in particular of the skin, wherein the substance is selected from the group consisting of anti-NKp65 antibody, anti-CLEC2A antibody soluble NKp65, soluble CLEC2A, or functional fragments thereof.