[The expression of IL-9, IL-17 and Foxp3 in nasal polyps].

Objective:To observe the expression of IL-9,IL-17and Foxp3in nasal polyps,so that to explore the role of Th9,Th17/Treg cells imbalance in pathogenesis of nasal polyposis.Method:Forty cases of nasal polyps and 20cases of normal middle turbinate mucosa(controls)were involved in this study.The expression patterns of IL-9,IL-17and Foxp3were detected by immunohistochemistry.Result:The positive rates of IL-9and IL-17in nasal polyps tissues were respectively 75.0%and 80.0%,which were both significantly higher than those in the controls(positive rates were 35.0%and 50.0%,respectively),but the Foxp3expression was downregulated in nasal polyps tissues(37.5%)compared to the controls(80.0%),P0.05respectively.Conclusion:The cytokines IL-9 and IL-17are obviously involved in the occurrence and development of nasal polyposis,suggesting remarkable infiltration of Th9and Th17/Treg imbalance exist in nasal polyps,both of which may play important roles in pathogenesis of nasal polyposis.