Lobular Carcinoma In Situ

Lobular carcinoma in situ (LCIS) is a high-risk atypical breast lesion associated with an increased risk of breast cancer in either breast. It is most often found incidentally during a breast biopsy. Management of classis LCIS focuses first on confirming radiology-pathology concordance for the imaging abnormality that was biopsied. Excisional biopsy should be performed for associated lesions such as masses or radial scar or discordant findings. If there are no high-risk features on biopsy, then management of LCIS should focus on breast cancer high-risk screening and risk reduction with hormonal therapy or surgery. Pleomorphic LCIS is a special subtype which should typically be excised to negative margins with surgical treatment and adjuvant therapy discussed in a multidisciplinary physician team.