Glucose-Dependent Regulation of NR2F2 Promoter and Influence of SNP-rs3743462 on Whole Body Insulin Sensitivity

Competing Interests: The authors have the following interest: This work was supported by grants from Merck Sharp & Dohme. The D.E.S.I.R. study has been supported by INSERM contracts with CNAMTS, Lilly, Novartis Pharma, and Sanofiaventis, ONIVINS, Ardix Medical, Bayer Diagnostics, Becton Dickinson, Cardionics, Merck Sante, Novo Nordisk, Pierre Fabre, Roche, and Topcon. This does not alter the authors’ adherence to all the PLoS ONE policies on sharing data and materials, as detailed online in the guide for authors. Funding: This work was supported by grants from the European Foundation for the Study of Diabetes and the program partner Merck Sharp & Dohme 2010 to M.V.-C., from the Contrat de Projets Etat-Region Nord-Pas-De-Calais (CPER 2007-2013 ‘Axe Cardio-Diabete’) to M.V. and P.F., and Centre National de la Recherche Scientifique (CNRS). The D.E.S.I.R. study has been supported by INSERM contracts with CNAMTS, Lilly, Novartis Pharma, and Sanofiaventis, and by INSERM (Reseaux en Sante Publique, Interactions entre les determinants de la sante, Cohortes Sante TGIR 2008), the Association Diabete Risque Vasculaire, the Federation Francaise de Cardiologie, La Fondation de France, ALFEDIAM, ONIVINS, Societe Francophone du Diabete, Ardix Medical, Bayer Diagnostics, Becton Dickinson, Cardionics, Merck Sante, Novo Nordisk, Pierre Fabre, Roche, and Topcon. Additional support came from the European Commission (EURO-BLCS, Framework 5 award QLG1-CT-2000-01643); NHLBI grant 5R01HL087679-02 through the STAMPEED program (1RL1MH083268-01); NIH/NIMH (5R01MH63706:02); ENGAGE project and grant agreement HEALTH-F4-2007-201413; and the Medical Research Council, UK (studentship grant G0500539). M.B. is the recipient of doctoral fellowships from the Ministere de l’Enseignement Superieur et de la Recherche and Association pour la Recherche sur le Cancer. O.H.P.R. was the recipient of a 12-month post-doctoral fellowship from Ile-de-France CODDIM 2008. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.