Biological gradient having an elastic modulus of biodegradable polyurethane fiber and preparation of tissue engineering scaffold

The present invention discloses a biodegradable polyurethanes, and preparation and use in the annulus fibrosus tissue engineering, biodegradable polyurethane has a modulus of elasticity gradient 1.5 ~ 15.0MPa, can be prepared by an electrostatic spinning process the fiber tissue engineering scaffold , annulus-derived stem cells can proliferate on the holder, and differentiation of stem cells modulus of elasticity in the regulation, in the high elastic modulus scaffold collagen type I gene expression is relatively high; and in the lower modulus of elasticity of the fiber holder higher gene expression than the type II collagen gene and glycosaminoglycans. The measurement results showed that the cell cells traction on the traction higher modulus of elasticity of the fiber holder is relatively small, cell traction on the fiber holder lower modulus of elasticity is relatively large, which differ from the actual radial region of annulus consistent. This provides the possibility for the development of a bionic regional differences can annulus of the annulus tissue engineering scaffolds.