Regulation of fat metabolism during resistance exercise in sedentary lean and obese men

The effect of acute resistance exercise (RE) on whole body energy expenditure (EE) and α2-adrenergic receptor (α2-AR) regulation of lipolysis in subcutaneous abdominal adipose tissue (SCAAT) was determined in sedentary lean (LN) and obese (OB) men. Lipolysis was monitored using microdialysis in 10 LN [body mass index (BMI) 20.9 ± 0.6] and 10 OB (BMI 36.2 ± 2.7) men before, during, and for 24 h after RE. EE was measured before and immediately after RE for 40 min. Changes in interstitial glycerol were measured in SCAAT with three microdialysis probes perfused with a control solution, phentolamine (α2-AR antagonist), or propranolol (β-AR antagonist). EE and fat oxidation (FOX) were significantly (P < 0.001) elevated immediately post-RE compared with pre-RE in LN and OB subjects, with no differences between groups. RE-induced increases in SCAAT glycerol concentrations from rest to peak exercise were greater in LN than in OB men in the control (LN 142.1 ± 30.8 vs. OB 65.4 ± 14.2%, P = 0.03) and phentolamine pr...