연구보문 : 복분자 에탄올 추출물의 생리활성 탐색

This study was carried out to evaluate biological activities to different ethanol extracts from unripened and ripened fruit (Rubus coreanus Miq.). 25% to 75% ethanol extracts of unripened and ripened fruits were similar to extract yield respectively. Yield of ethanol extract of ripened fruit were approximately 3 times higher than that of unripened fruit. 75% ethanol extract of unripened fruit showed the highest contents of total polyphenol (180.04 ± 0.41㎎/g) and total flavonoid (50.43 ± 0.81㎎/g). Contents of total polyphenol and total flavonoid of unripened fruit were about 2 times higher than those of ripened fruit. IC50 values of DPPH radical scavenging activity and linoleic acid peroxidation inhibition activity of BHA and α-tocopherol showed 13.19 ± 0.21 and 18.16 ± 0.23 ㎍/㎖, 4.25 ± 0.04 ㎍/㎖ and 5.56 ± 0.10 ㎍/㎖ respectively, but 75% ethanol extract of unripened fruit showed the lowest 23.85 ± 0.10 ㎍/㎖ and 7.34 ± 0.07 ㎍/㎖ among other all extracts. IC50 values of LDL (low density lipoprotein) oxidation inhibition activity and α-glucosidase inhibitory activity of 75% ethanol extract of unripened fruit showed the lowest 1.04 ± 0.04 ㎍/㎖ and 7.21 ± 0.13 ㎍/㎖ among other all extracts respectively. Specifically, 75% ethanol extract of unripened fruit has relatively better biological activities than other ethanol extracts, it could be potentially used as bioactive source for health functional foods.