Регуляторні патерни в оцінці функціонального стану організму дітей та підлітків із цукровим діабетом 1 типу

Objective — to further study the original method of assessment of functional status of organism of children and adolescents with type 1 diabetes. Materials and methods. We have examined 23 children with type 1 diabetes and 22 practically healthy schoolchildren. The research was conducted using FAZAGRAF ® diagnostic complex. The electrocardiogram (ECG) and heart rate variability (HRV) indices were calculated in a state of rest, at the height of stress and during a period of restitution, which form five classes of distinctive patterns. We determined distribution of patterns in groups. Results and discussion. For AMo and Stress Index the patterns of «Minimum» class are dominant, while for SDNN and RMSSD the patterns of «Maximum» class are dominant. In 26.1 % of afflicted children we observed «Minimum» class patterns atypical for SDNN and in 43.5 % — patterns atypical for RMSSD . There was in afflicted subjects an atypical reaction to stress for pNN 50 in 56.5 % of cases, while in healthy ones it was only in 9.5 % of cases (p = 0.95). For T ­wave symmetry (b Т ) we have identified atypical «Increase» patterns in 26.1 % of children with type 1 diabetes, compared to 14.3 % of healthy children. Similar reaction was also observed for standard quadratic deviation of T ­wave symmetry ( SD b T ). Conclusions. Identification of atypical patterns, which are descriptive of dynamics of HRV and ECG indices as a result of test with physical stress, in children and adolescents with type 1 diabetes can be considered statistically significant diagnostic marker of myocardial dysfunction.