Correction: The MITOP database – a one-stop shop for mitochondrial information

We apologise to the MITOP authors who were omitted from the previous announcement (Trends Genet. 14, 519). The full announcement is published here:The MITOP database—a one-stop shop for mitochondrial informationhttp://websvr.mips.biochem.mpg.de/proj/medgen/mitop/The MITOP database combines data on both nuclear- and mitochondrial-encoded genes and their proteins. Annotated data for more than 1000 mitochondria-related genes and corresponding proteins derived from a variety of online resources and the literature have been included in the five species files (S. cerevisiae, M. musculus, C. elegans, N. crassa and H. sapiens). MITOP provides a wide spectrum of search facilities in the interrelated sections ‘Gene catalogues’, ‘Protein catalogues’, ‘Homologies’, ‘Pathways and metabolism’, and ‘Human disease catalogue’, including extensive references and hyperlinks for each entry. A list of homologous proteins is provided for each protein entry, as well as precomputed FASTA searches using all the MITOP yeast protein entries designed to provide a list of the best human EST hits, with graphical cluster alignments related to the yeast reference sequence. To aid investigations into interspecies homology, we present orthologue tables with cross-listing of all the protein entries for each species in the database. Graphic depictions of several important mitochondrial processes are included, and a program (MITOPROT) is available to identify targeting sequences and calculate the probability of the import of proteins into mitochondria. The ‘Human disease catalogue’ lists 101 disorders related to mitochondrial protein abnormalities, sorted by clinical criteria and age of onset.