Anticonvulsant Activity of Schumanniophyton magnificum Roots Extracts in Mice
2004
Schumanniophyton magnificum , a highly valued medicinal plant in Nigeria and West African sub-region is widely used by traditional medical practitioners in the treatment of various ailments including epilepsy and convulsion. In order to evaluate this aspect of the folkloric use of the plant, the anticonvulsant effects of the S. magnificum ethanolic root extract were studied in mice, using picrotoxin and strychnine as convulsants.The extract (1000mg/kg) administered orally, 30 minutes prior to subcutaneous administration of picrotoxin (5mg/kg body weight) was found to confer a 100% protection on the animals. Also, a dose of 800mg/kg of the extract administered 30 minutes before subcutaneous administration of strychnine (4mg/kg body weight) prolonged the latency period of the induced seizures, and increased the time to death. The results of the study indicate that the extract has a protective effect on convulsions and this may provide a rationale for its local use in the management of episodes of seizure. Key Words: Anticonvulsant activity, medicinal plants, picrotoxin, Schumanniophyton magnificum, strychnine. Resume Schumanniophyton magnificium plante a grande valeur medicinale au Nigeria et dans la sous region Ouest- africaine. Est largement utilise par les tradi-praticiens dans le traitement de differents maux parmis lesquels l'epilepsy et la convulsion . dans le but d'evaluer cet aspect floklorique de l'utilisation de la plante; l'effet anticonvulsant des extraits a base d'ethanol de la racine du S. magnificium ont ete etudie sur des souris utilisant la picrotoxine et la strychinne comme anticonvulsant.
Des extraits (1000mg/kg) administre orallement 30minutes avant l'administration sous-cutanee des pricrotoxin(5mg/kg poids corporel) conferais aux animaux une protection de 100%. Des dose 800mg/kg des extaits administre 30 minute orallement avant administration sous-cutanee du strychnine (4mg/kg poids corporel) prolongeait la periode de latence des convulsions induites et augmentaient le temps de mort. Les resultats des etudes montre que les extraits ont un effet protecteur sur la convulsion et ceci peut etre la raison de son utilisation local pour le traitement des episode de convulsions. Mot cles: activite anticonvulsante ,plante medicinales , picrotoxine, Schumanniophyton magnificium, strychnine. West Afr. J. Pharmacol. Drug Res. Vol.19 (1&2) 2003: 33-36
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