General Two-Step Preparation of Chalcones Containing Thiazole.

2-Aryl-4-methyl-5-acetylthiazoles, which were prepared from arylthioamides and chloroacetylacetone, were treated with 6-substituted-3-formylchromones or arylaldehydes to give a series of eighteen new thiazolylchalcones in good yields. The structures of all the synthesized compounds were characterized by 1H NMR, 13C NMR, and ES-MS spectrometry. Additionally, the crystal structures of two of these chalcones were determined by X-ray diffraction analysis.