Mellaril in the treatment of chronically disturbed patients: with special reference to reduced extrapyramidal complications.

Moderate to marked improvement in psychomotor behavior was obtained with Mellaril in 17 of the 22 cases in this series. In addition, there was complete elimination of extrapyramidal activity in 15 of 18 patients who had manifested Parkinsonian symptoms with the drugs previously employed. Our observations indicate that Mellaril is equally effective, or more so, than other phenothiazines in the treatment of various psychiatric disorders, but has a distinctly lessened tendency to induce extrapyramidal stimulation. In our experience, this is a significant contribution to the more effective management of larger numbers of disturbed patients.