Prevalence and influencing factors of chronic hepatitis B virus infection complicated with chronic kidney disease

Objective To investigate the prevalence and influencing factors of chronic hepatitis B virus (HBV) infection complicated with chronic kidney disease. Methods From July 2016 to July 2017, the patients with chronic HBV infection were selected from Beijing Ditan Hospital, Capital Medical University. According to the serum creatinine (Scr) level and age of the subjects, the MDRD-equation was used to calculate the glomerular filtration rate (GFR) of the patients, and the prevalence rate of chronic kidney disease in the target population was estimated and the risk factors affecting the prevalence were analyzed. Results Total of 6 665 patients with chronic HBV infection were collected, including 4 457 males and 2 208 females; 607 HBV carriers, 4 630 patients with chronic hepatitis B and 1 428 patients with liver cirrhosis after hepatitis B. The prevalence rate of chronic kidney disease (CKD) in patients with eGFR < 60 ml/min/1.73 m2and 60≤eGFR < 90ml/min/1.73 m2were 72 cases (1.08%) and 586 cases (8.79%), respectively, which was higher of male patients than that of women, but with no significant differences (χ2= 0.52,P = 0.473). The prevalence of CKD increased with age increasing and the difference was significant among patients with different ages (χ2= 356.71,P< 0.001). The prevalence rate of CKD in patients with cirrhosis (3.15%) was significantly higher than that in patients of HBV carrier (0.16%) and chronic hepatitis B (0.59%), with significant difference (χ2= 144.00, P< 0.001). Conclusions Chronic HBV infection is associated with disease progression and CKD prevalence. Age, cirrhosis, hypertension and diabetes are all independent risk factors for CKD in patients with chronic HBV infection. Key words: Chronic hepatitis B virus infection; Chronic kidney disease; Estimated glomerular filtration rate; Prevalence; Risk factor