THE PROCESSES OF LIPOPEROXIDATION AND ENDOGENOUS INTOXICATION IN SALIVA IN CENTRAL AND PERIPHERAL LUNG CANCER

: The aim of the study was to establish the patterns of changes in the parameters of endogenous intoxication and lipoperoxidation processes in the saliva of patients with lung cancer, depending on the form of tumor growth (central, peripheral or mediastinal cancer). Materials and methods: in the case - control study was attended by 562 volunteers, who were divided into 2 groups: main (lung cancer, n = 347) and control group (relatively healthy, n = 2015). Questioning, biochemical saliva study and histological verification of the diagnosis carried out to all participants. In peripheral lung cancer, there is a statistically significant increase in the albumin concentration (p<0.0001), with a central MDA (p=0.0330). The content of secondary lipoperoxidation products compared with the control is increased for all groups (p<0.0001), however, the differences are most pronounced for the mediastinal growth form. The level of medium molecular toxins is the same for both central and peripheral lung cancer, and the distribution coefficient has a stable value exceeding the corresponding value for the control group (p=0.0002). Thus, in the peripheral form of lung cancer growth under hypoxic conditions lipoperoxidation processes are less pronounced, while endotoxicosis processes are the same in both central and peripheral cancer. For the mediastinal growth, the process of lipoperoxidation is directed towards the formation of toxic Schiff bases, and the low level of medium-molecular toxins indicates a greater resistance of proteins to oxidative stress.