Clinical study on reversing hepatic fibrosis with Handan Ganle ( Open image in new window ) capsule) capsule

Objective: To observe the therapeutic effect on hepatic fibrosis of chronic hepatitis B by Chinese medicine—Handan Ganle capsule (HDGLC).Methods: A total of 104 patients with chronic hepatitis B has been treated by HDGLC for 6 months, liver fibrosis indexes and the serum biochemical indexes were detected before treatment, during the curative period and by the end of treatment. Hepatic biopsy was performed before or after the treatment.Results: The improvement rate of clinical symptoms was 79.0% - 90.6%, and the recovery rate of ALT was 72.6 %, serum fibrosis indexes such as HA, type IV collagen and LN were significantly decreased along with the extending course of disease (P < 0.05). The pathohistological score of liver was decreased from 7.82 ± 6.22 before treatment to 5.16 ± 3.75 after treatment (P < 0.05) and the score of hepatic fibrosis was decreased from 7.49 ± 5.45 before treatment to 5.16 ± 4.26 after treatment (P < 0.05).Conclusion: HDGLC has remarkable therapeutic and reversing effect on chronic hepatitis B induced hepatic fibrosis.