A multi-ancestry genome-wide study incorporating gene-smoking interactions identifies multiple new loci for pulse pressure and mean arterial pressure

Yun Ju Sung,L. de las Fuentes,Thomas W. Winkler,Daniel I. Chasman,Amy R. Bentley,Aldi T. Kraja,Ioanna Ntalla,Helen R. Warren,Xiuqing Guo,Karen Schwander,Alisa K. Manning,Michael R. Brown,Hugues Aschard,Mary F. Feitosa,Nora Franceschini,Yingchang Lu,Cheng C-Y.,Xueling Sim,Dina Vojinovic,Jonathan Marten,Solomon K. Musani,Tuomas O. Kilpeläinen,Melissa A. Richard,Stella Aslibekyan,Traci M. Bartz,Rajkumar Dorajoo,Changwei Li,Yongmei Liu,Tuomo Rankinen,Albert V. Smith,Salman M. Tajuddin,Bamidele O. Tayo,Wei Zhao,Yanhua Zhou,Nana Matoba,Tamar Sofer,Maris Alver,Marzyeh Amini,Mathilde Boissel,Jin Fang Chai,Xu Chen,Jasmin Divers,Ilaria Gandin,Chuan Gao,Franco Giulianini,Anuj Goel,Sarah E. Harris,Fernando Pires Hartwig,M He,Horimoto Arvr.,Hsu F-C.,Anne U. Jackson,C M Kammerer,Anuradhani Kasturiratne,P. Komulainen,Brigitte Kühnel,K Leander,Lee W-J,Lin K-H.,Jianan Luan,Lyytikäinen L-P.,C A McKenzie,Christopher P. Nelson,Raymond Noordam,Robert A. Scott,Sheu Whh,Alena Stančáková,Fumihiko Takeuchi,P. J. van der Most,Tibor V. Varga,R J Waken,Heming Wang,Yajuan Wang,Erin B. Ware,Scott T Weiss,Wanqing Wen,Lisa R. Yanek,Weihua Zhang,Jing Hua. Zhao,Saima Afaq,Tamuno Alfred,Najaf Amin,Dan E. Arking,Tin Aung,R. G. Barr,L.F. Bielak,Eric Boerwinkle,Erwin P. Bottinger,Peter S. Braund,Jennifer A. Brody,Ulrich Broeckel,Brian E. Cade,Archie Campbell,Mickaël Canouil,Aravinda Chakravarti,Massimiliano Cocca,Francis S. Collins,John M. Connell,R. de Mutsert,H.J. de Silva,Marcus Dörr,Qing Duan,Charles B. Eaton,Georg B. Ehret,Evangelos Evangelou,Jessica D. Faul,Nita G. Forouhi,Oscar H. Franco,Yechiel Friedlander,He Gao,Bruna Gigante,Chi Charles Gu,Preeti Gupta,Saskia P. Hagenaars,Tamara B. Harris,Jiang He,Sami Heikkinen,Heng C-K.,Albert Hofman,Barbara V. Howard,Steven C. Hunt,Marguerite R. Irvin,Yucheng Jia,Tomohiro Katsuya,Joel D. Kaufman,Nicola D. Kerrison,Chiea Chuen Khor,Koh W-P.,Heikki A. Koistinen,Charles Kooperberg,J E Krieger,Michiaki Kubo,Zoltán Kutalik,Johanna Kuusisto,Timo A. Lakka,Carl D. Langefeld,Claudia Langenberg,L. J. Launer,Joseph H. Lee,Benjamin Lehne,Denise J. Levy,Cora E. Lewis,Yize Li,Sing Hui Lim,Liu C-T.,Jianjun Liu,Marie Loh,Kurt Lohman,Tin Louie,Reedik Mägi,Koichi Matsuda,Thomas Meitinger,Andres Metspalu,L Milani,Yukihide Momozawa,Thomas H. Mosley,Mike A. Nalls,U Nasri,Jeffery R. O’Connell,Adesola Ogunniyi,Walter Palmas,Nicholette D. Palmer,James S. Pankow,Nancy L. Pedersen,Annette Peters,Patricia A. Peyser,Ozren Polasek,David J. Porteous,Olli T. Raitakari,Frida Renström,Treva Rice,Paul M. Ridker,Antonietta Robino,Jennifer G. Robinson,Lynda M. Rose,Igor Rudan,Charumathi Sabanayagam,Babatunde L. Salako,Kevin Sandow,C. O. Schmidt,Pamela J. Schreiner,William R. Scott,Peter S Sever,Mario Sims,Colleen M. Sitlani,Blair H. Smith,Jennifer A. Smith,Harold Snieder,John M. Starr,Konstantin Strauch,Hua Tang,Kent D. Taylor,Yik Ying Teo,Yih Chung Tham,André G. Uitterlinden,M Waldenberger,Lihua Wang,Yunpeng Wang,Wen Bin Wei,Gregory Wilson,Mary K. Wojczynski,Xiang Y-B.,Jie Yao,Yuan J-M.,Alan B. Zonderman,Diane M. Becker,Michael Boehnke,Donald W. Bowden,Jenny Chambers,Chen Y-Di.,David R. Weir,U. de Faire,Ian J. Deary,Tõnu Esko,Martin Farrall,T. Forrester,Barry I. Freedman,Philippe Froguel,P. Gasparini,Christian Gieger,Bernardo L Horta,Hung Y-J.,Jost B. Jonas,Norihiro Kato,Jaspal S. Kooner,Markku Laakso,Terho Lehtimäki,Liang K-W.,Magnusson Pke.,Albertine J. Oldehinkel,Alexandre C. Pereira,Thomas T. Perls,Rainer Rauramaa,Susan Redline,Rainer Rettig,Nilesh J. Samani,James Scott,Shu X-O.,P. van der Harst,Lynne E. Wagenknecht,Nicholas J. Wareham,Hugh Watkins,Ananda R. Wickremasinghe,Tangchun Wu,Yoichiro Kamatani,Cathy C. Laurie,Claude Bouchard,Richard S. Cooper,Michele K. Evans,Vilmundur Gudnason,James E. Hixson,Kardia Slr.,Stephen B. Kritchevsky,Bruce M. Psaty,R. M. van Dam,Donna K. Arnett,Dennis O. Mook-Kanamori,Myriam Fornage,Ervin R. Fox,Caroline Hayward,C. M. van Duijn,E S Tai,Tien Yin Wong,Loos Rjf.,Alexander P. Reiner,Charles N. Rotimi,Laura J. Bierut,Xiaofeng Zhu,L A Cupples,M. A. Province,Jerome I. Rotter,Paul W. Franks,Ken Rice,Paul Elliott,Mark J. Caulfield,W J Gauderman,Patricia B. Munroe,D. C. Rao,Alanna C. Morrison

A multi-ancestry genome-wide study incorporating gene-smoking interactions identifies multiple new loci for pulse pressure and mean arterial pressure

2019

Yun Ju Sung
L. de las Fuentes
Thomas W. Winkler
Daniel I. Chasman
Amy R. Bentley
Aldi T. Kraja
Ioanna Ntalla
Helen R. Warren
Xiuqing Guo
Karen Schwander
Alisa K. Manning
Michael R. Brown
Hugues Aschard
Mary F. Feitosa
Nora Franceschini
Yingchang Lu
Cheng C-Y.
Xueling Sim
Dina Vojinovic
Jonathan Marten
Solomon K. Musani
Tuomas O. Kilpeläinen
Melissa A. Richard
Stella Aslibekyan
Traci M. Bartz
Rajkumar Dorajoo
Changwei Li
Yongmei Liu
Tuomo Rankinen
Albert V. Smith
Salman M. Tajuddin
Bamidele O. Tayo
Wei Zhao
Yanhua Zhou
Nana Matoba
Tamar Sofer
Maris Alver
Marzyeh Amini
Mathilde Boissel
Jin Fang Chai
Xu Chen
Jasmin Divers
Ilaria Gandin
Chuan Gao
Franco Giulianini
Anuj Goel
Sarah E. Harris
Fernando Pires Hartwig
M He
Horimoto Arvr.
Hsu F-C.
Anne U. Jackson
C M Kammerer
Anuradhani Kasturiratne
P. Komulainen
Brigitte Kühnel
K Leander
Lee W-J
Lin K-H.
Jianan Luan
Lyytikäinen L-P.
C A McKenzie
Christopher P. Nelson
Raymond Noordam
Robert A. Scott
Sheu Whh
Alena Stančáková
Fumihiko Takeuchi
P. J. van der Most
Tibor V. Varga
R J Waken
Heming Wang
Yajuan Wang
Erin B. Ware
Scott T Weiss
Wanqing Wen
Lisa R. Yanek
Weihua Zhang
Jing Hua. Zhao
Saima Afaq
Tamuno Alfred
Najaf Amin
Dan E. Arking
Tin Aung
R. G. Barr
L.F. Bielak
Eric Boerwinkle
Erwin P. Bottinger
Peter S. Braund
Jennifer A. Brody
Ulrich Broeckel
Brian E. Cade
Archie Campbell
Mickaël Canouil
Aravinda Chakravarti
Massimiliano Cocca
Francis S. Collins
John M. Connell
R. de Mutsert
H.J. de Silva
Marcus Dörr
Qing Duan
Charles B. Eaton
Georg B. Ehret
Evangelos Evangelou
Jessica D. Faul
Nita G. Forouhi
Oscar H. Franco
Yechiel Friedlander
He Gao
Bruna Gigante
Chi Charles Gu
Preeti Gupta
Saskia P. Hagenaars
Tamara B. Harris
Jiang He
Sami Heikkinen
Heng C-K.
Albert Hofman
Barbara V. Howard
Steven C. Hunt
Marguerite R. Irvin
Yucheng Jia
Tomohiro Katsuya
Joel D. Kaufman
Nicola D. Kerrison
Chiea Chuen Khor
Koh W-P.
Heikki A. Koistinen
Charles Kooperberg
J E Krieger
Michiaki Kubo
Zoltán Kutalik
Johanna Kuusisto
Timo A. Lakka
Carl D. Langefeld
Claudia Langenberg
L. J. Launer
Joseph H. Lee
Benjamin Lehne
Denise J. Levy
Cora E. Lewis
Yize Li
Sing Hui Lim
Liu C-T.
Jianjun Liu
Marie Loh
Kurt Lohman
Tin Louie
Reedik Mägi
Koichi Matsuda
Thomas Meitinger
Andres Metspalu
L Milani
Yukihide Momozawa
Thomas H. Mosley
Mike A. Nalls
U Nasri
Jeffery R. O’Connell
Adesola Ogunniyi
Walter Palmas
Nicholette D. Palmer
James S. Pankow
Nancy L. Pedersen
Annette Peters
Patricia A. Peyser
Ozren Polasek
David J. Porteous
Olli T. Raitakari
Frida Renström
Treva Rice
Paul M. Ridker
Antonietta Robino
Jennifer G. Robinson
Lynda M. Rose
Igor Rudan
Charumathi Sabanayagam
Babatunde L. Salako
Kevin Sandow
C. O. Schmidt
Pamela J. Schreiner
William R. Scott
Peter S Sever
Mario Sims
Colleen M. Sitlani
Blair H. Smith
Jennifer A. Smith
Harold Snieder
John M. Starr
Konstantin Strauch
Hua Tang
Kent D. Taylor
Yik Ying Teo
Yih Chung Tham
André G. Uitterlinden
M Waldenberger
Lihua Wang
Yunpeng Wang
Wen Bin Wei
Gregory Wilson
Mary K. Wojczynski
Xiang Y-B.
Jie Yao
Yuan J-M.
Alan B. Zonderman
Diane M. Becker
Michael Boehnke
Donald W. Bowden
Jenny Chambers
Chen Y-Di.
David R. Weir
U. de Faire
Ian J. Deary
Tõnu Esko
Martin Farrall
T. Forrester
Barry I. Freedman
Philippe Froguel
P. Gasparini
Christian Gieger
Bernardo L Horta
Hung Y-J.
Jost B. Jonas
Norihiro Kato
Jaspal S. Kooner
Markku Laakso
Terho Lehtimäki
Liang K-W.
Magnusson Pke.
Albertine J. Oldehinkel
Alexandre C. Pereira
Thomas T. Perls
Rainer Rauramaa
Susan Redline
Rainer Rettig
Nilesh J. Samani
James Scott
Shu X-O.
P. van der Harst
Lynne E. Wagenknecht
Nicholas J. Wareham
Hugh Watkins
Ananda R. Wickremasinghe
Tangchun Wu
Yoichiro Kamatani
Cathy C. Laurie
Claude Bouchard
Richard S. Cooper
Michele K. Evans
Vilmundur Gudnason
James E. Hixson
Kardia Slr.
Stephen B. Kritchevsky
Bruce M. Psaty
R. M. van Dam
Donna K. Arnett
Dennis O. Mook-Kanamori
Myriam Fornage
Ervin R. Fox
Caroline Hayward
C. M. van Duijn
E S Tai
Tien Yin Wong
Loos Rjf.
Alexander P. Reiner
Charles N. Rotimi
Laura J. Bierut
Xiaofeng Zhu
L A Cupples
M. A. Province
Jerome I. Rotter
Paul W. Franks
Ken Rice
Paul Elliott
Mark J. Caulfield
W J Gauderman
Patricia B. Munroe
D. C. Rao
Alanna C. Morrison

U.S. National Heart, Lung, and Blood Institute (NHLBI) (K25HL121091 to Y.J.S.); National Institutes of Health (R01HL118305).

Keywords:

Genetics
Genome
Mean arterial pressure
Locus (genetics)
Gene
Pulse pressure
Biology
Diastole
Genome-wide association study
Blood pressure
Heart failure
Insulin resistance

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